Full-time postdoctoral position at the laboratory of Proteostasis Control and Biomedicine of the University of Chile.

The Biomedical Neuroscience Institute (www.bni.cl) and the Geroscience Center for Brain Health and Metabolism (www.gerochile.cl) are seeking a highly-qualified and motivated applicant for a full -time postdoctoral position at the laboratory of Proteostasis Control and Biomedicine of the University of Chile. The lab has also formal activities at the Buck Institute for Research in Aging, California (www.buckinstitute.org) that could complement the postdoctoral training.

Post-Doc Position:

This position funded by international national grants project for a 3-year period. Starting date: June 2023 or later upon agreement. The candidates are requested to apply for ANID/FONDECYT grants Abril 2023 (not a requisite to obtain the grant).

Project:

The project is part of a larger initiative involving collaboration with different labs in the US, Europe and Chile, and is focused on assessing the relationship between protein misfolding, aging and proteostasis. Neurodegenerative diseases, brain cancer and gene therapy are desired research subjects, in addition to mechanistic studies (cell biology).  This laboratory focuses on understanding the molecular basis of proteostasis control and its relationship to pathological conditions affecting the nervous system. The project aims to the study cellular strategies involved in adaptation to chronic endoplasmic reticulum (ER) stress. The ER has important cellular functions, highlighting its role as sophisticated machinery for protein folding and secretion. ER stress engages an integrated signaling pathway known as the “Unfolded Protein Response” (UPR), which aims to restore homeostasis. Nevertheless, the mechanisms that control the transition from an adaptive state to cell death processes remain unknown and is a central subject of our research. We are currently developing a systematic approach to underscore the effects of targeting the UPR in several brain diseases. He/she investigates signal transduction pathways regulating stress pathways (UPR, autophagy and apoptosis). Furthermore, he/she supports the Chair in teaching and student supervision. This lab is the most cited group in the field in Chile (https://research.com/scientists-rankings/biology-and-biochemistry/cl) and is part of the top 1% most cited labs in the world (Clarivate, Web of Science 2021 and 2022).

Qualifications:

Candidates are expected to hold a PhD in Biology or similar education, preferentially with several years of experience. Furthermore, a strong practical and theoretical background and experience in protein biochemistry, cell biology, molecular biology and/or animal experimentation is of advantage. Good English language skills required. Complete applications, including CV, publication list and 2 references should be submitted to

Dr. Claudio Hetz (chetz@uchile.cl) or call +56 (2) 29786506. Website: www.hetzlab.cl

fecha publicación: 03 abril 2023